National Center for Biotechnology Information

National Center for Biotechnology Information is about health and sciences by providing access to biomedical and genomic information. 

Popular resources in this database are pubMed, bookshlef, nucleotide, genome, gene and protein. 

This database allows the users to submit the manuscripts to this database, find any help document, analyze and identify any database that related to your task and review any collaborative project or NCBI research project. 

example of gene protein 

Srpr (Signal Recognition Particle Receptor ) is one of the protein gene. When we search this type of gene protein, what we can find is about the summary of this gene, genomic context, genomic regions, transcripts and products, general gene information and general protein information. 

In this database, what we can learn is to understand nature's mute but elegant language of living cells in the quest of modern molecular biology. Nowadays, the challenge is in finding new approaches to deal with volume and the complexity of data that providing better access to analyzing and computing tools, so this database is platform to perform your new findings. 

Drug Adverse Reaction Target

An adverse drug reaction (ADR) often results from interaction of a drug or its metabolites with specific protein targets important in normal cellular function.There is a database that provide information for the drug adverse reaction target. You can check it here. 

Once you click the link, you'll see the database. Now, if you not sure what to do, you can click the 'here' button and read the descriptions.

Then, you may search the information that you needed. For example, I searched for amnesia adverse effect. 

Choose your target name. For example, platelet activating factor receptor.

Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a biologically active phospholipid mediator, potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. 

TTD: Therapeutic Target Design

A database to provide information about the known and explored therapeutic protein and nucleic acid targets, the targeted disease, pathway information and the corresponding drugs directed at each of these targets. 

Also included in this database are links to relevant databases containing information about target function, sequence, 3D structure, ligand binding properties, enzyme nomenclature and drug structure, therapeutic class and clinical development status

     

For instance, QSR models. 

1. Quantitative structure–activity relationship models (QSAR models) are regression or classification models used in the chemical and biological sciences and engineering.
2. 
   

click on the code TTDID

this is the reference for the model

A publicly accessible database that provides comprehensive information about these targets is therefore helpful to the relevant communities. The Therapeutic Target Database (TTD) is designed to provide information about the known therapeutic protein and nucleic acid targets described in the literature, the targeted disease conditions, the pathway information and the corresponding drugs/ligands directed at each of these targets. Cross-links to other databases are also introduced to facilitate the access of information about the sequence, 3D structure, function, nomenclature, drug/ligand binding properties, drug usage and effects, and related literature for each target.

THERAPEUTICALLY RELEVANT MULTIPLE PATHWAYS DATABASE

In this era of technology, any information can be access by a mouse click. Same goes to this topic. The Therapeutically Relevant Multiple Pathways Database is designed to provide disease processes involve cross-talks between proteins in different pathways. Therapeutic targets for different proteins can be used for the same disease. Synergistic targeting of multiple targets has been explored in combination therapy of a number of diseases. To facilitate mechanistic study of drug actions and a more comprehensive understanding the relationship between different targets of the same disease.

We can gather information from a specific websites such as NCBI, KEGG, OMIM, or even SwissProt to look for a specific disease. For instance, first, open up this website here. From there, search for the Therapeutically Relevant Multiple Pathways Database on the Database tab. Next, u can search for any diseases such as cancer on the multiple pathway box.

This multiple pathway related to cancer growth can be found. 

This website is so important in developing a database of known therapeutically relevant multiple pathways (TRMPs). Futhermore, the websites can also be used to facilitate the access of information about individual pathways and proteins which are useful not only for medical doctors, but for all of the community. By using these search engines, accessing information will be as easy as lifting a finger and increasing the quality of research effectiveness and allowing for better coordination of care.

Thank You.

PROTEIN DATABASE

page of Protein Data Bank

'http://www.pdb.org/'

The picture above shows the page of Protein Data Bank. These page was help us to know in dept about the structure of biology. The information was in 3D structures of the large biological molecules including the proteins and nucleic acid.

 In pharmaceutical industry, to design the drug the researcher must know detail about the structures of the molecule. As in this website, the researcher can understanding the shape of the molecule helps to understand better how it can works in our body. 

              As we put the TbrPDEB1-inhibitor complex the example to find the information. 

Molecular Description

Structure Validation

Ligand Chemical Component

 All the information about the protein inhibitor complex we can get from it including the classification, structure weight, molecules, polymer and many more. Its give benefits to us as to finding the suitable molecule or just to know detail about the molecule can functional well in our body.

Drugbank Database

What we can get from this database is about the bioinforamtics and cheminformatics resource that combines detailed drug for example chemical, pharmacological and pharmaceutical data with comprehensive drug target. 

This database also allows users to casually scroll through the database or resort it contents by clicking on drugscard button brings up the full data content for the corresponding drug. 

For example :

Pneumonia disease. When we search this type of disease, all information about the drug used to treat this disease we can get such as identification, taxonomy, pharmacology, ADMET, pharmacoeconomics, properties, spectra, references, targets and transporters. Sparfloxacin is example of drug used in pneumonia disease.

identification

taxonomy

pharmacology

properties 

drug interaction

target of drug 

This database might useful for the users who want to know about the drug that they are using. They can know about the target molecule of the drug and how the drug react in the body. All information that you need is in one website by typing any drugs that you want to know.  Thats all.

Thank you !

HUMANCYNC DATABASE

 

HumanCYC provides a reference on not only human genes, but also cover informations on proteins, metabolites or pathways. At the homepage, it states that HumanCYC prvides a "zoomable metabolic map diagram". Being user-friendly, HumanCYC has prepared a title written "Getting Started" containing instructions on how to use the website efficiently.

I typed in the protein name, "Actin" in the search box and pressed Enter. The first thing I noticed was the list of various types of actin which exist.

After clicking at the first link on the list, which is "7SK snRNA methylphosphate capping enzyme", this database gives me information on the Gene Local Context, Unification Links, Map Position, Synonyms, and Accession Number.

I think that this website would be extremely useful for anyone who's studying or doing research on human genomes as the widely important information are easily accessible with just a few clicks away on the computer.